InnateDB Protein
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IDBP-47906.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GLYAT
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Protein Name
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glycine-N-acyltransferase
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Synonyms
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ACGNAT; CAT; GAT;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000278400
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InnateDB Gene
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IDBG-47902 (GLYAT)
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Protein Structure
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Function |
Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid. {ECO:0000269PubMed:22475485, ECO:0000269PubMed:7802672}.
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Subcellular Localization |
Mitochondrion {ECO:0000269PubMed:22475485}.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in liver (at protein level) and kidney. Down-regulated in hepatocellular carcinoma and other liver cancers. {ECO:0000269PubMed:22475485}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0016746
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transferase activity, transferring acyl groups
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GO:0047961
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glycine N-acyltransferase activity
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GO:0047962
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glycine N-benzoyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR015938
Glycine N-acyltransferase, N-terminal
IPR016181
Acyl-CoA N-acyltransferase
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PFAM |
PF06021
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6IB77
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PhosphoSite |
PhosphoSite-Q6IB77
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
10249
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UniGene |
Hs.145384
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RefSeq |
NP_005829
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HUGO |
HGNC:13734
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OMIM |
607424
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CCDS |
CCDS7971
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HPRD |
07603
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IMGT |
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EMBL |
AB013093
AF023466
AP000445
BC009785
CR456927
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GenPept |
AAB81453
AAH09785
CAG33208
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