InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRPC1

Summary

InnateDB Protein

IDBP-479095.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRPC1

Protein Name

transient receptor potential cation channel, subfamily C, member 1

Synonyms

HTRP-1; TRP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000419313

InnateDB Gene

IDBG-59714 (TRPC1)

Protein Structure

UniProt Annotation

Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. {ECO:0000269PubMed:15016832}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Seems to be ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005261	cation channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0015279	store-operated calcium channel activity
GO:0044325	ion channel binding
GO:0070679	inositol 1,4,5 trisphosphate binding

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0007411	axon guidance
GO:0034220	ion transmembrane transport
GO:0046541	saliva secretion
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0051480	cytosolic calcium ion homeostasis
GO:0051592	response to calcium ion
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0030017	sarcomere
GO:0043034	costamere
GO:0043234	protein complex
GO:0043235	receptor complex
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

InterPro

IPR002110 Ankyrin repeat
IPR002153 Transient receptor potential channel, canonical
IPR004729 Transient receptor potential channel
IPR005457 Transient receptor potential channel, canonical 1
IPR005821 Ion transport domain
IPR013555 Transient receptor ion channel domain
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00023
PF13606
PF00520
PF08344
PF11929
PF12796

PRINTS

PR01415
PR01097
PR01642

PIRSF

SMART

SM00248

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt