InnateDB Protein
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IDBP-479230.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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H1FOO
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Protein Name
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H1 histone family, member O, oocyte-specific
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000422964
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InnateDB Gene
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IDBG-56105 (H1FOO)
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Protein Structure
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Function |
May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255PROSITE-ProRule:PRU00837}. Chromosome {ECO:0000255PROSITE-ProRule:PRU00837}.
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Disease Associations |
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Tissue Specificity |
Oocyte-specific. {ECO:0000269PubMed:12711322}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0031492
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nucleosomal DNA binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8IZA3
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PhosphoSite |
PhosphoSite-Q8IZA3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
132243
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UniGene |
Hs.97358
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RefSeq |
XP_005247180
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HUGO |
HGNC:18463
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OMIM |
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CCDS |
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HPRD |
13621
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IMGT |
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EMBL |
AY158091
BC047943
CH471052
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GenPept |
AAH47943
AAN46899
EAW79242
EAW79243
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