InnateDB Protein
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IDBP-479465.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MBD4
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Protein Name
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methyl-CpG binding domain protein 4
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Synonyms
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MED1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000424873
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InnateDB Gene
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IDBG-55837 (MBD4)
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Protein Structure
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Function |
Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. {ECO:0000269PubMed:10097147, ECO:0000269PubMed:10930409}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
29
[view]
|
Protein-Protein |
24
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001739
Methyl-CpG DNA binding
IPR011257
DNA glycosylase
IPR016177
DNA-binding domain
IPR017352
Methyl-CpG binding protein MBD4
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PFAM |
PF01429
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PRINTS |
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PIRSF |
PIRSF038005
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SMART |
SM00391
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TIGRFAMs |
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Modification |
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SwissProt |
O95243
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PhosphoSite |
PhosphoSite-O95243
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
8930
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UniGene |
Hs.692921
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RefSeq |
NP_001263201
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HUGO |
HGNC:6919
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OMIM |
603574
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CCDS |
CCDS63767
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HPRD |
04654
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IMGT |
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EMBL |
AF072250
AF114784
AF120997
AF120998
AF120999
AF494057
AF532602
AK303013
AL449212
AM180876
BC011752
CH471052
CR450305
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GenPept |
AAC68879
AAD22195
AAD50374
AAH11752
AAM00008
AAP97338
BAG64144
CAG29301
CAJ55826
EAW79251
EAW79253
EAW79254
EAW79255
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