InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ASH2L

Summary

InnateDB Protein

IDBP-479702.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ASH2L

Protein Name

ash2 (absent, small, or homeotic)-like (Drosophila)

Synonyms

ASH2; ASH2L1; ASH2L2; Bre2;

Species

Homo sapiens

Ensembl Protein

ENSP00000430259

InnateDB Gene

IDBG-17300 (ASH2L)

Protein Structure

UniProt Annotation

Function

Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis. {ECO:0000269PubMed:12670868, ECO:0000269PubMed:19556245}.

Subcellular Localization

Nucleus {ECO:0000305PubMed:17355966}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Predominantly expressed in adult heart and testis and fetal lung and liver, with barely detectable expression in adult lung, liver, kidney, prostate, and peripheral leukocytes. {ECO:0000269PubMed:10393421}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 117 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	117 [view]
Protein-Protein	111 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0042800	histone methyltransferase activity (H3-K4 specific)
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006974	cellular response to DNA damage stimulus
GO:0008284	positive regulation of cell proliferation
GO:0030097	hemopoiesis
GO:0043627	response to estrogen
GO:0051568	histone H3-K4 methylation