InnateDB Protein
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IDBP-479811.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GFRA2
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Protein Name
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GDNF family receptor alpha 2
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Synonyms
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GDNFRB; NRTNR-ALPHA; NTNRA; RETL2; TRNR2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000429206
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InnateDB Gene
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IDBG-9892 (GFRA2)
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Protein Structure
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Function |
Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Isoform 1 is found in both brain and placenta.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0007169
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transmembrane receptor protein tyrosine kinase signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR003438
Glial cell line-derived neurotrophic factor receptor
IPR003504
Glial cell line-derived neurotrophic factor receptor alpha 2
IPR016017
GDNF/GAS1
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PFAM |
PF02351
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PRINTS |
PR01316
PR01318
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PIRSF |
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SMART |
SM00907
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TIGRFAMs |
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Modification |
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SwissProt |
O00451
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PhosphoSite |
PhosphoSite-O00451
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
2675
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UniGene |
Hs.720276
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RefSeq |
NP_001158511
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HUGO |
HGNC:4244
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OMIM |
601956
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CCDS |
CCDS55207
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HPRD |
11801
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IMGT |
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EMBL |
AC105186
AC129925
AF002700
AP008236
AY326396
AY941828
BC041688
U93703
U97145
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GenPept |
AAB61922
AAC51647
AAC52036
AAH41688
AAP88378
AAX46325
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