InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LGR5

Summary

InnateDB Protein

IDBP-47984.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LGR5

Protein Name

leucine-rich repeat containing G protein-coupled receptor 5

Synonyms

FEX; GPR49; GPR67; GRP49; HG38;

Species

Homo sapiens

Ensembl Protein

ENSP00000266674

InnateDB Gene

IDBG-47982 (LGR5)

Protein Structure

UniProt Annotation

Function

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R- spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. {ECO:0000269PubMed:21693646, ECO:0000269PubMed:21727895, ECO:0000269PubMed:21909076, ECO:0000269PubMed:22815884, ECO:0000269PubMed:23809763}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans- Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653). {ECO:0000269PubMed:23439653}.

Disease Associations

Tissue Specificity

Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver. {ECO:0000269PubMed:12601349, ECO:0000269PubMed:16575208, ECO:0000269PubMed:19030762}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0048839	inner ear development
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0032588	trans-Golgi network membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000372 Leucine-rich repeat-containing N-terminal
IPR001611 Leucine-rich repeat
IPR002131 Glycoprotein hormone receptor family
IPR003591 Leucine-rich repeat, typical subtype
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001
PF01462
PF00560
PF13504
PF13855

PRINTS

PR00237
PR00373

PIRSF

SMART

SM00013
SM00369

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt