InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRLR

Summary

InnateDB Protein

IDBP-479938.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRLR

Protein Name

prolactin receptor

Synonyms

HPRL; hPRLrI; MFAB;

Species

Homo sapiens

Ensembl Protein

ENSP00000424841

InnateDB Gene

IDBG-15793 (PRLR)

Protein Structure

UniProt Annotation

Function

This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. {ECO:0000269PubMed:12580759, ECO:0000269PubMed:20032052}.

Subcellular Localization

Membrane {ECO:0000269PubMed:11518703, ECO:0000269PubMed:12580759}; Single-pass type I membrane protein {ECO:0000269PubMed:11518703, ECO:0000269PubMed:12580759}.Isoform 7: Secreted.

Disease Associations

Multiple fibroadenomas of the breast (MFAB) [MIM:615554]: A benign breast disease marked by lobuloalveolar growth with abnormally high proliferation of the epithelium, and characterized by the presence of more than 3 fibroadenomas in one breast. Fibroadenomas are adenomas containing fibrous tissue. {ECO:0000269PubMed:18779591}. Note=The disease is caused by mutations affecting the gene represented in this entry.Hyperprolactinemia (HPRL) [MIM:615555]: A disorder characterized by increased levels of prolactin in the blood not associated with gestation or the puerperium. HPRL may result in infertility, hypogonadism, and galactorrhea. {ECO:0000269PubMed:24195502}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in breast, placenta, kidney, liver and pancreas. {ECO:0000269PubMed:11518703, ECO:0000269PubMed:12580759}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	30 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004925	prolactin receptor activity
GO:0005515	protein binding
GO:0017046	peptide hormone binding
GO:0042803	protein homodimerization activity
GO:0042978	ornithine decarboxylase activator activity
GO:0046872	metal ion binding

Biological Process

GO:0006694	steroid biosynthetic process
GO:0007166	cell surface receptor signaling pathway
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity
GO:0007566	embryo implantation
GO:0007595	lactation
GO:0038161	prolactin signaling pathway
GO:0042110	T cell activation
GO:0042977	activation of JAK2 kinase activity
GO:0043066	negative regulation of apoptotic process
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway