Version 5.4
Homo sapiens Protein: SH3BP2
Summary
InnateDB Protein IDBP-479968.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH3BP2
Protein Name SH3-domain binding protein 2
Synonyms 3BP-2; 3BP2; CRBM; CRPM;
Species Homo sapiens
Ensembl Protein ENSP00000424846
InnateDB Gene IDBG-7639 (SH3BP2)
Protein Structure
UniProt Annotation
Function Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
Subcellular Localization
Disease Associations Cherubism (CRBM) [MIM:118400]: An autosomal dominant syndrome characterized by excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling. {ECO:0000269PubMed:11381256, ECO:0000269PubMed:12900899, ECO:0000269PubMed:14577811}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269PubMed:9734812}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 48 [view]
Protein-Protein 48 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
Biological Process
GO:0007165 signal transduction
GO:0009967 positive regulation of signal transduction
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000980 SH2 domain
IPR001849 Pleckstrin homology domain
PFAM PF00017
PF14633
PF00169
PRINTS PR00401
PIRSF
SMART SM00252
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P78314
PhosphoSite PhosphoSite-P78314
TrEMBL D6RER9
UniProt Splice Variant
Entrez Gene 6452
UniGene Hs.167679
RefSeq
HUGO HGNC:10825
OMIM 602104
CCDS CCDS33944
HPRD 03657
IMGT
EMBL AB000462 AB000463 AF000936 AK299996 AK312286 AL121750 BC022996 CH471131 U56386
GenPept AAB59973 AAB72034 AAH22996 BAA19119 BAA19120 BAG35213 BAG61816 EAW82509 EAW82510 EAW82511 EAW82512

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca