InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MLANA

Summary

InnateDB Protein

IDBP-48023.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MLANA

Protein Name

melan-A

Synonyms

MART-1; MART1;

Species

Homo sapiens

Ensembl Protein

ENSP00000370886

InnateDB Gene

IDBG-48021 (MLANA)

Protein Structure

UniProt Annotation

Function

Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes. {ECO:0000269PubMed:15695812, ECO:0000269PubMed:19717472}.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Note=Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post- Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.

Disease Associations

Tissue Specificity

Expression is restricted to melanoma and melanocyte cell lines and retina.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0005887	integral component of plasma membrane
GO:0042470	melanosome