InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: INPP4B

Summary

InnateDB Protein

IDBP-480316.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INPP4B

Protein Name

inositol polyphosphate-4-phosphatase, type II, 105kDa

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000425487

InnateDB Gene

IDBG-39125 (INPP4B)

Protein Structure

UniProt Annotation

Function

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed with highest levels occurring in the skeletal muscle and heart. {ECO:0000269PubMed:9295334}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0016316	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity
GO:0034594	phosphatidylinositol trisphosphate phosphatase activity
GO:0034597	phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0006874	cellular calcium ion homeostasis
GO:0007165	signal transduction
GO:0016311	dephosphorylation
GO:0043647	inositol phosphate metabolic process
GO:0044281	small molecule metabolic process
GO:0045671	negative regulation of osteoclast differentiation
GO:0046822	regulation of nucleocytoplasmic transport
GO:0046850	regulation of bone remodeling
GO:0051896	regulation of protein kinase B signaling