InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FAM162A

Summary

InnateDB Protein

IDBP-480502.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FAM162A

Protein Name

family with sequence similarity 162, member A

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000419088

InnateDB Gene

IDBG-52508 (FAM162A)

Protein Structure

UniProt Annotation

Function

Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly. {ECO:0000269PubMed:15082785}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Mitochondrion {ECO:0000269PubMed:15082785, ECO:0000269PubMed:16698020}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006927	transformed cell apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0051402	neuron apoptotic process
GO:0071456	cellular response to hypoxia
GO:0090200	positive regulation of release of cytochrome c from mitochondria