InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ALDH1L1

Summary

InnateDB Protein

IDBP-480667.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALDH1L1

Protein Name

aldehyde dehydrogenase 1 family, member L1

Synonyms

10-fTHF; 10-FTHFDH; FDH; FTHFD;

Species

Homo sapiens

Ensembl Protein

ENSP00000420293

InnateDB Gene

IDBG-54444 (ALDH1L1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Highly expressed in liver, pancreas and kidney. {ECO:0000269PubMed:20498374}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0008168	methyltransferase activity
GO:0016155	formyltetrahydrofolate dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0016742	hydroxymethyl-, formyl- and related transferase activity

Biological Process

GO:0006730	one-carbon metabolic process
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0009258	10-formyltetrahydrofolate catabolic process
GO:0032259	methylation
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002376 Formyl transferase, N-terminal
IPR005793 Formyl transferase, C-terminal
IPR009081 Acyl carrier protein-like
IPR011034 Formyl transferase, C-terminal-like
IPR011407 10-formyltetrahydrofolate dehydrogenase
IPR015590 Aldehyde dehydrogenase domain
IPR016161 Aldehyde/histidinol dehydrogenase

PFAM

PF00551
PF02911
PF00550
PF00171

PRINTS

PIRSF

PIRSF036489

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O75891