Version 5.4
Homo sapiens Protein: DEFB4B
Summary
InnateDB Protein IDBP-480680.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DEFB4B
Protein Name defensin, beta 4B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000424598
InnateDB Gene IDBG-6283 (DEFB4B)
Protein Structure
UniProt Annotation
Function Has antibacterial activity. {ECO:0000305}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed in the skin and respiratory tract.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006935 chemotaxis
GO:0006952 defense response
GO:0006955 immune response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0042742 defense response to bacterium
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005796 Golgi lumen
Protein Structure and Domains
PDB ID
InterPro IPR001855 Beta defensin type
IPR006080 Beta defensin/Neutrophil defensin
PFAM PF00711
PRINTS
PIRSF
SMART SM00048
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O15263
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 1673
UniGene Hs.740237
RefSeq NP_001192195
HUGO HGNC:30193
OMIM 602215
CCDS CCDS55193
HPRD
IMGT
EMBL AF040153 AF071216 AJ000152 BC069285 BC093983 BC093985 Z71389
GenPept AAC33549 AAC69554 AAH69285 AAH93983 AAH93985 CAA95992 CAB65126

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca