InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDCD6

Summary

InnateDB Protein

IDBP-480843.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDCD6

Protein Name

programmed cell death 6

Synonyms

ALG-2; PEF1B;

Species

Homo sapiens

Ensembl Protein

ENSP00000423815

InnateDB Gene

IDBG-409259 (PDCD6)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	51 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004198	calcium-dependent cysteine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0046983	protein dimerization activity
GO:0048306	calcium-dependent protein binding
GO:0060090	binding, bridging

Biological Process

GO:0001525	angiogenesis
GO:0001938	positive regulation of endothelial cell proliferation
GO:0006508	proteolysis
GO:0006886	intracellular protein transport
GO:0010595	positive regulation of endothelial cell migration
GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032007	negative regulation of TOR signaling
GO:0034605	cellular response to heat
GO:0036324	vascular endothelial growth factor receptor-2 signaling pathway
GO:0045766	positive regulation of angiogenesis
GO:0051592	response to calcium ion
GO:0051898	negative regulation of protein kinase B signaling
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0031410	cytoplasmic vesicle
GO:0031965	nuclear membrane
GO:0070062	extracellular vesicular exosome