Version 5.4
Homo sapiens Protein: TMEM8C
Summary
InnateDB Protein IDBP-480856.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM8C
Protein Name transmembrane protein 8C
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000419712
InnateDB Gene IDBG-91472 (TMEM8C)
Protein Structure
UniProt Annotation
Function Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Actively participates in the membrane fusion reaction (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localizes on the cell surface of myoblasts during fusion and is down-regulated thereafter. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007517 muscle organ development
GO:0007520 myoblast fusion
GO:0045026 plasma membrane fusion
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR021910 Protein of unknown function DUF3522
PFAM PF12036
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6NI61
PhosphoSite PhosphoSite-A6NI61
TrEMBL
UniProt Splice Variant
Entrez Gene 389827
UniGene Hs.512467
RefSeq NP_001073952
HUGO HGNC:33778
OMIM 615345
CCDS CCDS35170
HPRD
IMGT
EMBL BX324209
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca