Version 5.4
Homo sapiens Protein: SEPT6
Summary
InnateDB Protein IDBP-481103.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEPT6
Protein Name septin 6
Synonyms SEP2; SEPT2;
Species Homo sapiens
Ensembl Protein ENSP00000418715
InnateDB Gene IDBG-83838 (SEPT6)
Protein Structure
UniProt Annotation
Function Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. {ECO:0000269PubMed:17229681, ECO:0000269PubMed:17803907}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:15774761}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:15774761}. Chromosome, centromere, kinetochore {ECO:0000269PubMed:15774761}. Cleavage furrow {ECO:0000269PubMed:15774761}. Midbody {ECO:0000269PubMed:15774761}. Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:15915442}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 23 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0000910 cytokinesis
GO:0007049 cell cycle
GO:0016032 viral process
Cellular Component
GO:0000777 condensed chromosome kinetochore
GO:0005819 spindle
GO:0030496 midbody
GO:0031105 septin complex
GO:0032154 cleavage furrow
Protein Structure and Domains
PDB ID
InterPro IPR000038 Cell division protein GTP binding
IPR016491 Septin
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00735
PRINTS
PIRSF PIRSF006698
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14141
PhosphoSite PhosphoSite-Q14141
TrEMBL Q541S4
UniProt Splice Variant
Entrez Gene 23157
UniGene Hs.598119
RefSeq XP_006724812
HUGO HGNC:15848
OMIM 300683
CCDS CCDS14585
HPRD 06716
IMGT
EMBL AC004913 AC005052 AF403058 AF403059 AF403060 AF403061 AF403062 AK299273 AL355348 AY005981 AY034177 BC009291 BC011922 BC036240 CH471161 D50918
GenPept AAF97496 AAH09291 AAH11922 AAH36240 AAK61492 AAK98547 AAK98548 AAK98549 AAK98550 AAK98551 BAA09477 BAG61293 CAI41426 EAW89854 EAW89856

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca