InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDCD10

Summary

InnateDB Protein

IDBP-481246.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDCD10

Protein Name

programmed cell death 10

Synonyms

CCM3; TFAR15;

Species

Homo sapiens

Ensembl Protein

ENSP00000420553

InnateDB Gene

IDBG-64018 (PDCD10)

Protein Structure

UniProt Annotation

Function

Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Partially co- localizes with endogenous PXN at the leading edges of migrating cells.

Disease Associations

Cerebral cavernous malformations 3 (CCM3) [MIM:603285]: A congenital vascular anomaly of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters. {ECO:0000269PubMed:15543491}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:15543491}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.

Experimentally validated
Total	70 [view]
Protein-Protein	65 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0047485	protein N-terminus binding

Biological Process

GO:0001525	angiogenesis
GO:0006915	apoptotic process
GO:0008284	positive regulation of cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0043406	positive regulation of MAP kinase activity