InnateDB Protein
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IDBP-481460.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CSGALNACT1
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Protein Name
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chondroitin sulfate N-acetylgalactosaminyltransferase 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000429809
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InnateDB Gene
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IDBG-9548 (CSGALNACT1)
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Protein Structure
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Function |
Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage. {ECO:0000269PubMed:11788602, ECO:0000269PubMed:12163485, ECO:0000269PubMed:12446672, ECO:0000269PubMed:17145758}.
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Subcellular Localization |
Golgi apparatus, Golgi stack membrane {ECO:0000305PubMed:11788602}; Single-pass type II membrane protein {ECO:0000305PubMed:11788602}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland. Detected at low levels in the other tissues examined. {ECO:0000269PubMed:11788602, ECO:0000269PubMed:12163485, ECO:0000269PubMed:12446672}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0008376
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acetylgalactosaminyltransferase activity
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GO:0008955
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peptidoglycan glycosyltransferase activity
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GO:0015020
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glucuronosyltransferase activity
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GO:0016758
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transferase activity, transferring hexosyl groups
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GO:0046872
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metal ion binding
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GO:0047237
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glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
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GO:0047238
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glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
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Biological Process |
GO:0005975
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carbohydrate metabolic process
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GO:0007399
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nervous system development
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GO:0008037
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cell recognition
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GO:0008283
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cell proliferation
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GO:0009653
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anatomical structure morphogenesis
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GO:0015014
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heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
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GO:0019276
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UDP-N-acetylgalactosamine metabolic process
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GO:0030166
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proteoglycan biosynthetic process
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GO:0030198
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extracellular matrix organization
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GO:0030203
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glycosaminoglycan metabolic process
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GO:0030204
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chondroitin sulfate metabolic process
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GO:0030206
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chondroitin sulfate biosynthetic process
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GO:0030210
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heparin biosynthetic process
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GO:0044281
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small molecule metabolic process
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GO:0046398
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UDP-glucuronate metabolic process
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GO:0050650
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chondroitin sulfate proteoglycan biosynthetic process
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GO:0050651
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dermatan sulfate proteoglycan biosynthetic process
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GO:0050653
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chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR008428
Chondroitin N-acetylgalactosaminyltransferase
IPR029044
Nucleotide-diphospho-sugar transferases
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PFAM |
PF05679
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8TDX6
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PhosphoSite |
PhosphoSite-Q8TDX6
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TrEMBL |
E5RK93
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UniProt Splice Variant |
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Entrez Gene |
55790
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UniGene |
Hs.721954
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RefSeq |
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HUGO |
HGNC:24290
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OMIM |
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CCDS |
CCDS6010
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HPRD |
13114
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IMGT |
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EMBL |
AB071403
AB081516
AC090541
AC090786
AC116376
AK002126
AK314625
AL157483
AY358441
BC060772
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GenPept |
AAH60772
AAQ88806
BAA92093
BAB85992
BAC16217
BAG37191
CAB75673
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