InnateDB Protein
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IDBP-481613.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CXCL11
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Protein Name
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chemokine (C-X-C motif) ligand 11
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Synonyms
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b-R1; H174; I-TAC; IP-9; IP9; SCYB11; SCYB9B;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000425819
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InnateDB Gene
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IDBG-25238 (CXCL11)
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Protein Structure
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Function |
Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
16
[view]
|
Protein-Protein |
9
[view]
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Protein-DNA |
7
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001089
CXC chemokine
IPR001811
Chemokine interleukin-8-like domain
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PFAM |
PF00048
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PRINTS |
PR00437
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PIRSF |
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SMART |
SM00199
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TIGRFAMs |
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Modification |
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SwissProt |
O14625
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PhosphoSite |
PhosphoSite-O14625
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TrEMBL |
Q96KF0
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UniProt Splice Variant |
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Entrez Gene |
6373
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UniGene |
Hs.632592
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RefSeq |
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HUGO |
HGNC:10638
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OMIM |
604852
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CCDS |
CCDS3574
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HPRD |
05329
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IMGT |
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EMBL |
AF002985
AF030514
AF053972
AF077867
AF352781
BC005292
BC012532
BC110986
BT006787
U59286
U66096
Y15220
Y15221
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GenPept |
AAB17374
AAC39775
AAC51845
AAD10206
AAD38327
AAD38867
AAH05292
AAH12532
AAI10987
AAK52900
AAP35433
CAA75510
CAB51859
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