InnateDB Protein
|
IDBP-481779.4
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
WWC1
|
Protein Name
|
WW and C2 domain containing 1
|
Synonyms
|
HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000427772
|
InnateDB Gene
|
IDBG-56833 (WWC1)
|
Protein Structure
|
|
Function |
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance. {ECO:0000269PubMed:15081397, ECO:0000269PubMed:16684779, ECO:0000269PubMed:18190796, ECO:0000269PubMed:18596123, ECO:0000269PubMed:18672031, ECO:0000269PubMed:20159598, ECO:0000269PubMed:23778582}.
|
Subcellular Localization |
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Cell projection, ruffle membrane. Note=Colocalizes with PRKCZ in the perinuclear region.
|
Disease Associations |
|
Tissue Specificity |
Expressed in mammary epithelial cells and breast cancer cell lines. Found in the luminal epithelium surrounding the ducts in the normal breast. In the brain, expressed in somatodendritic compartment of neurons in the cortex and hippocampus and in the cerebellum it is found in the Purkinje cells and some granule cells (at protein level). Detected in brain, heart, colon and kidney. In the kidney, expressed in glomerular podocytes, in some tubules and in the collecting duct. {ECO:0000269PubMed:12559952, ECO:0000269PubMed:18190796, ECO:0000269PubMed:18596123, ECO:0000269PubMed:18672031}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
26
[view]
|
Protein-Protein |
26
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000008
C2 domain
IPR001202
WW domain
|
PFAM |
PF00168
PF00397
|
PRINTS |
PR00360
|
PIRSF |
|
SMART |
SM00239
SM00456
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8IX03
|
PhosphoSite |
PhosphoSite-Q8IX03
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
23286
|
UniGene |
Hs.484047
|
RefSeq |
NP_001155134
|
HUGO |
HGNC:29435
|
OMIM |
610533
|
CCDS |
CCDS54945
|
HPRD |
10033
|
IMGT |
|
EMBL |
AB020676
AC020894
AC026689
AF506799
AF530058
AK296323
AY189820
BC004394
BC017746
BX640827
|
GenPept |
AAH04394
AAH17746
AAO15881
AAO73817
AAQ09942
BAA74892
BAG59017
CAE45903
|
|
|