Version 5.4
Homo sapiens Protein: EPGN
Summary
InnateDB Protein IDBP-482203.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPGN
Protein Name epithelial mitogen homolog (mouse)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000426678
InnateDB Gene IDBG-24347 (EPGN)
Protein Structure
UniProt Annotation
Function Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases. {ECO:0000269PubMed:15611079}.
Subcellular Localization Isoform 1: Membrane {ECO:0000305}; Single- pass type I membrane protein {ECO:0000305}.Isoform 2: Membrane {ECO:0000305}; Single- pass type I membrane protein {ECO:0000305}.Isoform 3: Secreted {ECO:0000305}.Isoform 4: Secreted {ECO:0000305}.Isoform 5: Secreted {ECO:0000305}.Isoform 6: Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004708 MAP kinase kinase activity
GO:0005154 epidermal growth factor receptor binding
GO:0008083 growth factor activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0001525 angiogenesis
GO:0008284 positive regulation of cell proliferation
GO:0043406 positive regulation of MAP kinase activity
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0045840 positive regulation of mitosis
GO:0050679 positive regulation of epithelial cell proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6UW88
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 255324
UniGene Hs.401237
RefSeq NP_001257921
HUGO HGNC:17470
OMIM
CCDS CCDS59479
HPRD 10866
IMGT
EMBL AK289455 AY358920 DQ235264 DQ235265 DQ235266 DQ235267 DQ235268 DQ235269
GenPept AAQ89279 ABB60043 ABB60044 ABB60045 ABB60046 ABB60047 ABB60048 BAF82144

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca