Version 5.4
Homo sapiens Protein: B3GALNT1
Summary
InnateDB Protein IDBP-482281.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol B3GALNT1
Protein Name beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
Synonyms B3GALT3; beta3Gal-T3; galT3; Gb4Cer; GLCT3; GLOB; P; P1;
Species Homo sapiens
Ensembl Protein ENSP00000420163
InnateDB Gene IDBG-63670 (B3GALNT1)
Protein Structure
UniProt Annotation
Function Transfers N-acetylgalactosamine onto globotriaosylceramide. {ECO:0000269PubMed:10993897}.
Subcellular Localization Golgi apparatus membrane; Single-pass type II membrane protein.
Disease Associations
Tissue Specificity Higher expression in heart and brain, and to a lesser extent in lung, placenta, kidney and testis. Lower expression in liver, spleen and stomach. No expression in skeletal muscle. {ECO:0000269PubMed:10993897, ECO:0000269PubMed:9582303}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008378 galactosyltransferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0047273 galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity
Biological Process
GO:0006486 protein glycosylation
Cellular Component
GO:0000139 Golgi membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR002659 Glycosyl transferase, family 31
IPR003378 Fringe-like
PFAM PF01762
PF02434
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75752
PhosphoSite PhosphoSite-O75752
TrEMBL R4X604
UniProt Splice Variant
Entrez Gene 8706
UniGene Hs.723510
RefSeq NP_149359
HUGO HGNC:918
OMIM 603094
CCDS CCDS3193
HPRD 09119
IMGT
EMBL AB050855 AB050856 AB060691 AC021649 AF132731 AF154848 AF494103 AF494105 AF494106 AY359049 AY505345 AY505347 BC047618 CH471052 CR457170 DQ158095 FR871176 Y15062
GenPept AAF66442 AAF72106 AAH47618 AAM96009 AAM96011 AAM96012 AAQ89408 AAS79229 AAS79231 AAZ67917 BAB17690 BAB17691 BAB91079 CAA75346 CAG33451 CCB78514 EAW78621 EAW78623 EAW78624 EAW78625

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca