InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATXN3

Summary

InnateDB Protein

IDBP-482384.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATXN3

Protein Name

ataxin 3

Synonyms

AT3; ATX3; JOS; MJD; MJD1; SCA3;

Species

Homo sapiens

Ensembl Protein

ENSP00000426697

InnateDB Gene

IDBG-16734 (ATXN3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 107 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	107 [view]
Protein-Protein	107 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008242	omega peptidase activity
GO:0031625	ubiquitin protein ligase binding
GO:0042802	identical protein binding
GO:0051117	ATPase binding
GO:0061578	Lys63-specific deubiquitinase activity
GO:1990380	Lys48-specific deubiquitinase activity

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0006289	nucleotide-excision repair
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006508	proteolysis
GO:0006515	misfolded or incompletely synthesized protein catabolic process
GO:0007268	synaptic transmission
GO:0007399	nervous system development
GO:0008219	cell death
GO:0010810	regulation of cell-substrate adhesion
GO:0030036	actin cytoskeleton organization
GO:0035520	monoubiquitinated protein deubiquitination
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045104	intermediate filament cytoskeleton organization
GO:0070536	protein K63-linked deubiquitination
GO:0071108	protein K48-linked deubiquitination
GO:0071218	cellular response to misfolded protein