InnateDB Protein
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IDBP-482466.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SMG7
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Protein Name
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smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
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Synonyms
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C1orf16; EST1C; SGA56M;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000421358
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InnateDB Gene
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IDBG-105301 (SMG7)
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Protein Structure
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Function |
Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. {ECO:0000269PubMed:15546618, ECO:0000269PubMed:15721257}.
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Subcellular Localization |
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR019458
Telomerase activating protein Est1
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PFAM |
PF10374
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q92540
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PhosphoSite |
PhosphoSite-Q92540
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TrEMBL |
Q96N31
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UniProt Splice Variant |
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Entrez Gene |
9887
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UniGene |
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RefSeq |
NP_963862
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HUGO |
HGNC:16792
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OMIM |
610964
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CCDS |
CCDS53444
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HPRD |
10723
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IMGT |
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EMBL |
AB085674
AK056035
AK299178
AL137800
AL355387
AL359876
AL449223
BC036381
BC052565
D87437
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GenPept |
AAH36381
AAH52565
BAA13381
BAB71079
BAC53621
BAG61224
CAI16627
CAI19486
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