InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SKP1

Summary

InnateDB Protein

IDBP-482658.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SKP1

Protein Name

S-phase kinase-associated protein 1

Synonyms

EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L;

Species

Homo sapiens

Ensembl Protein

ENSP00000429686

InnateDB Gene

IDBG-44621 (SKP1)

Protein Structure

UniProt Annotation

Function

Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) direct ubiquitination of TTI1 and TELO2. SCF(FBXO10) direct ubiquitination of BCL2. {ECO:0000269PubMed:16209941, ECO:0000269PubMed:20181953, ECO:0000269PubMed:22113614, ECO:0000269PubMed:23431138}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 280 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	280 [view]
Protein-Protein	279 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007219	Notch signaling pathway
GO:0016032	viral process
GO:0016567	protein ubiquitination
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0035518	histone H2A monoubiquitination
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

Cellular Component

GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0019005	SCF ubiquitin ligase complex
GO:0031467	Cul7-RING ubiquitin ligase complex
GO:0031519	PcG protein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001232 SKP1 component
IPR011333 BTB/POZ fold
IPR016072 SKP1 component, dimerisation
IPR016073 SKP1 component, POZ domain
IPR016897 E3 ubiquitin ligase, SCF complex, Skp subunit

PFAM

PF01466
PF03931

PRINTS

PIRSF

PIRSF028729

SMART

SM00512

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt