Version 5.4
Homo sapiens Protein: CD99L2
Summary
InnateDB Protein IDBP-482716.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD99L2
Protein Name CD99 molecule-like 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000417697
InnateDB Gene IDBG-88792 (CD99L2)
Protein Structure
UniProt Annotation
Function Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Cell junction {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in many tissues, with low expression in thymus. {ECO:0000269PubMed:12706889}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007155 cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
Protein Structure and Domains
PDB ID
InterPro IPR022078 CD99 antigen-like protein 2
PFAM PF12301
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TCZ2
PhosphoSite PhosphoSite-Q8TCZ2
TrEMBL
UniProt Splice Variant
Entrez Gene 83692
UniGene Hs.701870
RefSeq NP_604395
HUGO HGNC:18237
OMIM 300846
CCDS CCDS14698
HPRD
IMGT
EMBL AF002223 AF274573 AK125020 AK290200 AK291375 AK293244 AL136580 AY078165 AY078166 AY078167 AY358837 BC025729 BC030536 CH471169
GenPept AAH25729 AAH30536 AAL86617 AAL86618 AAL86619 AAQ89196 BAF82889 BAF84064 BAG54124 BAG56778 CAB66515 EAW99391 EAW99392 EAW99393 EAW99395

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca