Homo sapiens Protein: TMPRSS11A
Summary
InnateDB Protein IDBP-483224.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMPRSS11A
Protein Name transmembrane protease, serine 11A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000426911
InnateDB Gene IDBG-21213 (TMPRSS11A)
Protein Structure
UniProt Annotation
Function Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in esophagus, liver, colon and lung. Down-regulated in esophagus cancers. {ECO:0000269PubMed:10920976}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007049 cell cycle
Cellular Component
GO:0005576 extracellular region
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR000082 SEA domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR017329 Peptidase S1A, HAT/DESC1
PFAM PF01390
PF00089
PRINTS PR00722
PIRSF PIRSF037941
SMART SM00200
SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZMR5
PhosphoSite PhosphoSite-Q6ZMR5
TrEMBL B5MDI9
UniProt Splice Variant
Entrez Gene 339967
UniGene Hs.450110
RefSeq
HUGO HGNC:27954
OMIM 611704
CCDS
HPRD 07123
IMGT
EMBL AC096653 AC096727 AF071882 AK131518 AY498712 BC111796 BN000133 CH471057
GenPept AAD41463 AAI11797 AAS78642 BAD18660 CAD67985 EAX05560