InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL33

Summary

InnateDB Protein

IDBP-48354.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL33

Protein Name

interleukin 33

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000370842

InnateDB Gene

IDBG-48350 (IL33)

Protein Structure

UniProt Annotation

Function

Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). {ECO:0000269PubMed:16286016, ECO:0000269PubMed:17853410, ECO:0000269PubMed:18836528}.In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin- associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100). {ECO:0000269PubMed:18787100, ECO:0000269PubMed:21734074}.

Subcellular Localization

Nucleus. Chromosome. Cytoplasmic vesicle, secretory vesicle. Secreted. Note=Associates with heterochromatin and mitotic chromosomes. Translocation from the nucleus occurs upon biomechanical strain, depends on an intact microtubule network, and is ATP-dependent.

Disease Associations

Tissue Specificity

Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta. {ECO:0000269PubMed:12819012}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	19 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding

Biological Process

GO:0002686	negative regulation of leukocyte migration
GO:0002826	negative regulation of T-helper 1 type immune response
GO:0002830	positive regulation of type 2 immune response
GO:0006351	transcription, DNA-templated
GO:0010628	positive regulation of gene expression
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032689	negative regulation of interferon-gamma production
GO:0032736	positive regulation of interleukin-13 production
GO:0032753	positive regulation of interleukin-4 production
GO:0032754	positive regulation of interleukin-5 production
GO:0032755	positive regulation of interleukin-6 production
GO:0043032	positive regulation of macrophage activation
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050729	positive regulation of inflammatory response
GO:0051024	positive regulation of immunoglobulin secretion
GO:0051025	negative regulation of immunoglobulin secretion
GO:0090197	positive regulation of chemokine secretion
GO:0097191	extrinsic apoptotic signaling pathway