InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PEX5L

Summary

InnateDB Protein

IDBP-483769.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PEX5L

Protein Name

peroxisomal biogenesis factor 5-like

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000418440

InnateDB Gene

IDBG-66475 (PEX5L)

Protein Structure

UniProt Annotation

Function

Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Some fraction is membrane associated via its interaction with RAB8B. {ECO:0000250}.

Disease Associations

Tissue Specificity

Mainly expressed in brain. Also expressed in pancreas, testis and pituitary. {ECO:0000269PubMed:11463335}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000268	peroxisome targeting sequence binding
GO:0005052	peroxisome matrix targeting signal-1 binding
GO:0005515	protein binding
GO:0031267	small GTPase binding

Biological Process

GO:0016558	protein import into peroxisome matrix
GO:0016560	protein import into peroxisome matrix, docking
GO:0043949	regulation of cAMP-mediated signaling