InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTK2

Summary

InnateDB Protein

IDBP-484119.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTK2

Protein Name

PTK2 protein tyrosine kinase 2

Synonyms

FADK; FAK; FAK1; FRNK; p125FAK; pp125FAK; PPP1R71;

Species

Homo sapiens

Ensembl Protein

ENSP00000429129

InnateDB Gene

IDBG-37147 (PTK2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 166 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	166 [view]
Protein-Protein	165 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008432	JUN kinase binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0042169	SH2 domain binding

Biological Process

GO:0001525	angiogenesis
GO:0001890	placenta development
GO:0001934	positive regulation of protein phosphorylation
GO:0003007	heart morphogenesis
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0007165	signal transduction
GO:0007172	signal complex assembly
GO:0007229	integrin-mediated signaling pathway
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0008360	regulation of cell shape
GO:0009790	embryo development
GO:0010594	regulation of endothelial cell migration
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0022408	negative regulation of cell-cell adhesion
GO:0030010	establishment of cell polarity
GO:0030168	platelet activation
GO:0030335	positive regulation of cell migration
GO:0032319	regulation of Rho GTPase activity
GO:0033628	regulation of cell adhesion mediated by integrin
GO:0038007	netrin-activated signaling pathway
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042127	regulation of cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087	innate immune response (InnateDB)
GO:0045667	regulation of osteoblast differentiation
GO:0045860	positive regulation of protein kinase activity
GO:0046777	protein autophosphorylation
GO:0048013	ephrin receptor signaling pathway
GO:0048870	cell motility
GO:0051493	regulation of cytoskeleton organization
GO:0051893	regulation of focal adhesion assembly
GO:0051897	positive regulation of protein kinase B signaling
GO:0060396	growth hormone receptor signaling pathway
GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000811	negative regulation of anoikis

Cellular Component

GO:0005634	nucleus
GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005925	focal adhesion
GO:0005938	cell cortex

Protein Structure and Domains

PDB ID

InterPro

IPR000299 FERM domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR005189 Focal adhesion kinase, targeting (FAT) domain
IPR011009 Protein kinase-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR029071 Ubiquitin-related domain

PFAM

PF00069
PF07714
PF03623
PF00373

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00295
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt