InnateDB Protein
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IDBP-484187.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PDS5A
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Protein Name
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PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
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Synonyms
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SCC-112; SCC112;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000426749
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InnateDB Gene
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IDBG-14730 (PDS5A)
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Protein Structure
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Function |
Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269PubMed:15855230, ECO:0000269PubMed:19907496}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:11076961, ECO:0000269PubMed:15019998}. Note=Associated with chromatin through most of the cell cycle. Dissociates from chromatin in late prophase, reassociates during late telophase. {ECO:0000269PubMed:11076961, ECO:0000269PubMed:15019998}.
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Disease Associations |
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Tissue Specificity |
Highest level in colon. Low levels in lung, ovary, breast and kidney. Reduced level in renal tumor tissue. Isoform 2 is expressed in kidney. {ECO:0000269PubMed:15019998}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
54
[view]
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Protein-Protein |
53
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR016024
Armadillo-type fold
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q29RF7
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PhosphoSite |
PhosphoSite-Q29RF7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
23244
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UniGene |
Hs.700053
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RefSeq |
NP_001093870
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HUGO |
HGNC:29088
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OMIM |
613200
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CCDS |
CCDS54759
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HPRD |
11537
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IMGT |
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EMBL |
AB014548
AF294791
AK098331
AY550968
BC041361
BC114218
BC126225
CR749425
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GenPept |
AAH41361
AAI14219
AAI26226
AAM82347
AAT52214
BAA31623
BAC05286
CAH18263
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