Version 5.4
Homo sapiens Protein: BRCA1
Summary
InnateDB Protein IDBP-484235.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BRCA1
Protein Name breast cancer 1, early onset
Synonyms BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PPP1R53; PSCP; RNF53;
Species Homo sapiens
Ensembl Protein ENSP00000419103
InnateDB Gene IDBG-52172 (BRCA1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 625 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 625 [view]
Protein-Protein 603 [view]
Protein-DNA 15 [view]
Protein-RNA 0
DNA-DNA 7 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006281 DNA repair
GO:0016567 protein ubiquitination
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF13639
PF14634
PF00097
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q92897
UniProt Splice Variant
Entrez Gene 672
UniGene Hs.622171
RefSeq
HUGO HGNC:1100
OMIM 113705
CCDS
HPRD 00218
IMGT
EMBL AB621825 AC135721 BC106745 DQ116737 HE600034 HE600035 HE600036 HE600037 HE600038 U37574 U61268
GenPept AAB40910 AAC50330 AAI06746 AAZ16492 BAK64160 CCD57770 CCD57771 CCD57772 CCD57773 CCD57774

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca