Version 5.4
Homo sapiens Protein: TIMMDC1
Summary
InnateDB Protein IDBP-484317.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TIMMDC1
Protein Name translocase of inner mitochondrial membrane domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000418803
InnateDB Gene IDBG-51251 (TIMMDC1)
Protein Structure
UniProt Annotation
Function Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I. {ECO:0000269PubMed:24191001}.
Subcellular Localization Mitochondrion membrane {ECO:0000269PubMed:24191001}; Multi-pass membrane protein {ECO:0000269PubMed:24191001}.
Disease Associations
Tissue Specificity Generalized expression enhanced in heart and skeletal muscle. {ECO:0000269PubMed:11092749}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane
Protein Structure and Domains
PDB ID
InterPro IPR003397 Mitochondrial inner membrane translocase subunit Tim17/Tim22/Tim23/peroxisomal protein PMP24
PFAM PF02466
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NPL8
PhosphoSite PhosphoSite-Q9NPL8
TrEMBL
UniProt Splice Variant
Entrez Gene 51300
UniGene Hs.614623
RefSeq NP_057673
HUGO HGNC:1321
OMIM 615534
CCDS CCDS33831
HPRD 12817
IMGT
EMBL AF139077 AF210057 AL136622 AL390077 AL390090 AL390094 AY358633 BC012341 CH471052 CR457158 CR533524
GenPept AAF62372 AAG43510 AAH12341 AAQ88996 CAB66557 CAB98201 CAB98212 CAB98251 CAG33439 CAG38555 EAW79566 EAW79568

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca