InnateDB Protein
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IDBP-484340.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IFNE
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Protein Name
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interferon, epsilon
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000418018
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InnateDB Gene
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IDBG-54354 (IFNE)
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Protein Structure
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Function |
Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity). {ECO:0000250}.
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Subcellular Localization |
Secreted {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Endometrium-specific. {ECO:0000269PubMed:23449591}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000471
Interferon alpha/beta/delta
IPR009079
Four-helical cytokine-like, core
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PFAM |
PF00143
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PRINTS |
PR00266
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PIRSF |
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SMART |
SM00076
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TIGRFAMs |
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Modification |
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SwissProt |
Q86WN2
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PhosphoSite |
PhosphoSite-Q86WN2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
338376
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UniGene |
Hs.682604
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RefSeq |
NP_795372
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HUGO |
HGNC:18163
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OMIM |
615223
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CCDS |
CCDS34997
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HPRD |
17132
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IMGT |
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EMBL |
AY190045
AY358570
BC100871
BC100872
BC100873
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GenPept |
AAI00872
AAI00873
AAI00874
AAO38686
AAQ88933
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