Homo sapiens Protein: BAP1
InnateDB Protein IDBP-484468.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BAP1
Protein Name BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
Synonyms HUCEP-13; UCHL2;
Species Homo sapiens
Ensembl Protein ENSP00000417132
InnateDB Gene IDBG-38830 (BAP1)
Protein Structure
UniProt Annotation
Function Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'- linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor. {ECO:0000269PubMed:12485996, ECO:0000269PubMed:18757409, ECO:0000269PubMed:19117993, ECO:0000269PubMed:19188440, ECO:0000269PubMed:19815555, ECO:0000269PubMed:20436459, ECO:0000269PubMed:24703950, ECO:0000269PubMed:9528852}.
Subcellular Localization Cytoplasm. Nucleus. Note=Mainly nuclear. Binds to chromatin. Localizes to the cytoplasm when monoubiquitinated by the E2/E3 hybrid ubiquitin-protein ligase UBE2O (PubMed:24703950). {ECO:0000269PubMed:24703950}.
Disease Associations Mesothelioma, malignant (MESOM) [MIM:156240]: An aggressive neoplasm of the serosal lining of the chest. It appears as broad sheets of cells, with some regions containing spindle- shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. {ECO:0000269PubMed:21642991, ECO:0000269PubMed:21874000}. Note=The gene represented in this entry is involved in disease pathogenesis.Tumor predisposition syndrome (TPDS) [MIM:614327]: A condition characterized by predisposition to develop a variety of tumors, including benign melanocytic tumors as well as several malignant tumors, including uveal melanoma, cutaneous melanoma, malignant mesothelioma on exposure to asbestos, lung adenocarcinoma and meningioma. {ECO:0000269PubMed:21874003}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Highly expressed in testis, placenta and ovary. Expressed in breast. {ECO:0000269PubMed:9528852}.
Number of Interactions This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 60 [view]
Protein-Protein 60 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008233 peptidase activity
Biological Process
GO:0001558 regulation of cell growth
GO:0006464 cellular protein modification process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008285 negative regulation of cell proliferation
GO:0016579 protein deubiquitination
GO:0035520 monoubiquitinated protein deubiquitination
GO:0035522 monoubiquitinated histone H2A deubiquitination
GO:0051726 regulation of cell cycle
GO:0071108 protein K48-linked deubiquitination
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0035517 PR-DUB complex
Protein Structure and Domains
InterPro IPR001578 Peptidase C12, ubiquitin carboxyl-terminal hydrolase
PFAM PF01088
Post-translational Modifications
SwissProt Q92560
PhosphoSite PhosphoSite-Q92560
UniProt Splice Variant
Entrez Gene 8314
UniGene Hs.622728
RefSeq NP_004647
OMIM 603089
HPRD 04366
EMBL AC092045 AF045581 AK292608 AY130008 BC001596 CH471055 D87462 D88812
GenPept AAC15970 AAH01596 AAN05092 BAA13401 BAB46921 BAF85297 EAW65220 EAW65221