Version 5.4
Homo sapiens Protein: HSPB7
Summary
InnateDB Protein IDBP-484504.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSPB7
Protein Name heat shock 27kDa protein family, member 7 (cardiovascular)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000419477
InnateDB Gene IDBG-91256 (HSPB7)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cytoplasm {ECO:0000269PubMed:19464326}. Nucleus {ECO:0000269PubMed:19464326}. Nucleus, Cajal body {ECO:0000269PubMed:19464326}. Note=Resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
Disease Associations
Tissue Specificity Isoform 1 is highly expressed in adult and fetal heart, skeletal muscle, and at a much lower levels in adipose tissue and in aorta. Undetectable in other tissues. Isoform 2 and isoform 3 are poorly detected in heart.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0006986 response to unfolded protein
GO:0008016 regulation of heart contraction
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0015030 Cajal body
Protein Structure and Domains
PDB ID
InterPro IPR001436 Alpha crystallin/Heat shock protein
IPR002068 Alpha crystallin/Hsp20 domain
IPR008978 HSP20-like chaperone
PFAM PF00011
PRINTS PR00299
PIRSF PIRSF036514
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UBY9
PhosphoSite PhosphoSite-Q9UBY9
TrEMBL
UniProt Splice Variant
Entrez Gene 27129
UniGene Hs.739310
RefSeq
HUGO HGNC:5249
OMIM 610692
CCDS
HPRD 13684
IMGT
EMBL AF155908 AJ243191 AK057295 AL096775 AL355994 BC006319 CR749298
GenPept AAF20022 AAH06319 BAG51899 CAB63258 CAB86671 CAH18153

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca