InnateDB Protein
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IDBP-48484.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PATL1
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Protein Name
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protein associated with topoisomerase II homolog 1 (yeast)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000300146
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InnateDB Gene
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IDBG-48482 (PATL1)
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Protein Structure
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Function |
RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV). {ECO:0000269PubMed:17936923, ECO:0000269PubMed:19628699, ECO:0000269PubMed:20543818, ECO:0000269PubMed:20584987, ECO:0000269PubMed:20852261}.
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Subcellular Localization |
Cytoplasm, P-body. Nucleus. Nucleus, PML body. Nucleus speckle. Note=Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Enriched in splicing speckles. Localization to nuclear foci and speckles requires active transcription. Excluded from the nucleolus.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. {ECO:0000269PubMed:17936923}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
13
[view]
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Protein-Protein |
13
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0000288
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nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
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GO:0000290
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deadenylation-dependent decapping of nuclear-transcribed mRNA
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GO:0010467
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gene expression
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GO:0016070
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RNA metabolic process
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GO:0016071
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mRNA metabolic process
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GO:0033962
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cytoplasmic mRNA processing body assembly
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GO:0043928
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exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
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Cellular Component |
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PDB ID |
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InterPro |
IPR019167
Topoisomerase II-associated protein PAT1
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PFAM |
PF09770
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q86TB9
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PhosphoSite |
PhosphoSite-Q86TB9
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TrEMBL |
B3KXN0
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UniProt Splice Variant |
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Entrez Gene |
219988
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UniGene |
Hs.619558
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RefSeq |
NP_689929
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HUGO |
HGNC:26721
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OMIM |
614660
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CCDS |
CCDS44613
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HPRD |
08214
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IMGT |
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EMBL |
AB065087
AK094193
AK127649
AK127943
AL831992
AP000442
AP000640
BC065264
BC109038
BC109039
BC111047
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GenPept |
AAH65264
AAI09039
AAI09040
AAI11048
BAB93524
BAC04305
BAG54542
BAG54601
CAD89916
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