InnateDB Protein
|
IDBP-484847.4
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
TNFAIP8
|
Protein Name
|
tumor necrosis factor, alpha-induced protein 8
|
Synonyms
|
GG2-1; MDC-3.13; NDED; SCC-S2; SCCS2;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000421848
|
InnateDB Gene
|
IDBG-38402 (TNFAIP8)
|
Protein Structure
|
|
Function |
Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. {ECO:0000269PubMed:10644768, ECO:0000269PubMed:11346652, ECO:0000269PubMed:14724590}.
|
Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:14724590}.
|
Disease Associations |
|
Tissue Specificity |
Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine- activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle. {ECO:0000269PubMed:10233894, ECO:0000269PubMed:10644768, ECO:0000269PubMed:14724590}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
15
[view]
|
Protein-Protein |
15
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0043027
|
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
|
|
Biological Process |
GO:0043066
|
negative regulation of apoptotic process
|
GO:0043154
|
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR008477
Protein of unknown function DUF758
|
PFAM |
PF05527
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
O95379
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
E5RIJ3
|
UniProt Splice Variant |
|
Entrez Gene |
25816
|
UniGene |
Hs.656274
|
RefSeq |
NP_055165
|
HUGO |
HGNC:17260
|
OMIM |
612111
|
CCDS |
CCDS47258
|
HPRD |
18204
|
IMGT |
|
EMBL |
AC008475
AC027320
AC035144
AF070671
AF098933
AF099935
AF099936
AK001850
AK001931
AK301281
BC005352
BC007014
CH471086
CR457137
|
GenPept |
AAC72975
AAC72976
AAC83229
AAF29435
AAH05352
AAH07014
BAG50983
BAG50994
BAH13449
CAG33418
EAW48914
|
|
|