InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADCY5

Summary

InnateDB Protein

IDBP-485073.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADCY5

Protein Name

adenylate cyclase 5

Synonyms

AC5; FDFM;

Species

Homo sapiens

Ensembl Protein

ENSP00000419361

InnateDB Gene

IDBG-52972 (ADCY5)

Protein Structure

UniProt Annotation

Function

This is a membrane-bound, calcium-inhibitable adenylyl cyclase.

Subcellular Localization

Membrane; Multi-pass membrane protein. Cell projection, cilium {ECO:0000250}.

Disease Associations

Dyskinesia, familial, with facial myokymia (FDFM) [MIM:606703]: A disorder characterized by predominantly perioral and periorbital myokymia, and face, neck and upper limb dystonic/choreic movements. Initially paroxysmal and worsened by stress, the dyskinetic episodes become nearly constant by the end of the third decade of life, but in some individuals, they may diminish in frequency and severity at older ages. {ECO:0000269PubMed:22782511}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004016	adenylate cyclase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008179	adenylate cyclase binding
GO:0016849	phosphorus-oxygen lyase activity
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001973	adenosine receptor signaling pathway
GO:0006112	energy reserve metabolic process
GO:0006171	cAMP biosynthetic process
GO:0006833	water transport
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007268	synaptic transmission
GO:0007626	locomotory behavior
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009190	cyclic nucleotide biosynthetic process
GO:0034199	activation of protein kinase A activity
GO:0035556	intracellular signal transduction
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050885	neuromuscular process controlling balance
GO:0055085	transmembrane transport
GO:0071377	cellular response to glucagon stimulus