InnateDB Protein
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IDBP-485114.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CCNC
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Protein Name
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cyclin C
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Synonyms
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CycC;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000428982
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InnateDB Gene
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IDBG-94598 (CCNC)
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Protein Structure
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Function |
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. {ECO:0000269PubMed:16595664, ECO:0000269PubMed:8700522}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
45
[view]
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Protein-Protein |
44
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0000079
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regulation of cyclin-dependent protein serine/threonine kinase activity
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GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006367
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transcription initiation from RNA polymerase II promoter
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GO:0007179
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transforming growth factor beta receptor signaling pathway
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GO:0007219
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Notch signaling pathway
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GO:0010467
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gene expression
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0051726
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regulation of cell cycle
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Cellular Component |
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PDB ID |
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InterPro |
IPR006671
Cyclin, N-terminal
IPR013763
Cyclin-like
IPR023598
Cyclin C
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PFAM |
PF00134
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PRINTS |
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PIRSF |
PIRSF028758
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SMART |
SM00385
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TIGRFAMs |
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Modification |
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SwissProt |
P24863
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PhosphoSite |
PhosphoSite-P24863
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TrEMBL |
Q7Z4L3
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UniProt Splice Variant |
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Entrez Gene |
892
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UniGene |
Hs.635390
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RefSeq |
NP_005181
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HUGO |
HGNC:1581
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OMIM |
123838
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CCDS |
CCDS34502
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HPRD |
00456
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IMGT |
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EMBL |
AB125137
AK298558
AL137784
BC010135
BC041123
BC056153
CH471051
M74091
U40728
U40729
U40730
U40731
U40732
U40733
U40734
U40735
U40736
U40737
U40738
U40739
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GenPept |
AAC50825
AAH10135
AAH41123
AAH56153
BAD00144
BAG60753
CAC14563
EAW48465
EAW48466
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