InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GFRA2

Summary

InnateDB Protein

IDBP-485413.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GFRA2

Protein Name

GDNF family receptor alpha 2

Synonyms

GDNFRB; NRTNR-ALPHA; NTNRA; RETL2; TRNR2;

Species

Homo sapiens

Ensembl Protein

ENSP00000429445

InnateDB Gene

IDBG-9892 (GFRA2)

Protein Structure

UniProt Annotation

Function

Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 is found in both brain and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0019898	extrinsic component of membrane
GO:0031225	anchored component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003438 Glial cell line-derived neurotrophic factor receptor
IPR003504 Glial cell line-derived neurotrophic factor receptor alpha 2
IPR016017 GDNF/GAS1
IPR017372 Glial cell line-derived neurotrophic factor receptor, alpha 1/2

PFAM

PF02351

PRINTS

PR01316
PR01318

PIRSF

PIRSF038071

SMART

SM00907

TIGRFAMs

Post-translational Modifications

Modification

Cross-References