InnateDB Protein
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IDBP-485420.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CST7
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Protein Name
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cystatin F (leukocystatin)
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Synonyms
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CMAP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000420384
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InnateDB Gene
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IDBG-60667 (CST7)
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Protein Structure
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|
Function |
Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system.
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Subcellular Localization |
Secreted {ECO:0000269PubMed:12423348}. Cytoplasm {ECO:0000269PubMed:12423348}.
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Disease Associations |
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Tissue Specificity |
Primarily expressed in peripheral blood cells and spleen.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
|
Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
|
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Predicted by orthology |
Total |
1 [view]
|
|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000010
Proteinase inhibitor I25, cystatin
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PFAM |
PF00031
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PRINTS |
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PIRSF |
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SMART |
SM00043
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TIGRFAMs |
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Modification |
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SwissProt |
O76096
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PhosphoSite |
PhosphoSite-O76096
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TrEMBL |
|
UniProt Splice Variant |
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Entrez Gene |
8530
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UniGene |
|
RefSeq |
NP_003641
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HUGO |
HGNC:2479
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OMIM |
603253
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CCDS |
CCDS13165
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HPRD |
04458
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IMGT |
|
EMBL |
AB015225
AB029636
AF031824
AF036342
AJ510167
AJ510168
AJ510169
AJ510170
AL035661
BC015507
BT009825
CR541860
CR541878
|
GenPept |
AAC35747
AAC39788
AAH15507
AAP88827
BAA34941
BAB11886
CAB75498
CAD52872
CAG46658
CAG46676
|
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