InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UHMK1

Summary

InnateDB Protein

IDBP-485561.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UHMK1

Protein Name

U2AF homology motif (UHM) kinase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000420270

InnateDB Gene

IDBG-104384 (UHMK1)

Protein Structure

UniProt Annotation

Function

Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:23419774}.

Disease Associations

Tissue Specificity

Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes. {ECO:0000269PubMed:12093740}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	8 [view]
Protein-DNA	3 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019899	enzyme binding
GO:0043021	ribonucleoprotein complex binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007050	cell cycle arrest
GO:0018105	peptidyl-serine phosphorylation
GO:0031175	neuron projection development
GO:0045948	positive regulation of translational initiation
GO:0046777	protein autophosphorylation
GO:0046825	regulation of protein export from nucleus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030424	axon
GO:0032839	dendrite cytoplasm
GO:0071598	neuronal ribonucleoprotein granule

Protein Structure and Domains

PDB ID

InterPro

IPR000504 RNA recognition motif domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00076
PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00360
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt