InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHIT1

Summary

InnateDB Protein

IDBP-485634.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHIT1

Protein Name

chitinase 1 (chitotriosidase)

Synonyms

CHI3; CHIT; CHITD;

Species

Homo sapiens

Ensembl Protein

ENSP00000423778

InnateDB Gene

IDBG-105936 (CHIT1)

Protein Structure

UniProt Annotation

Function

Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity. {ECO:0000269PubMed:7592832, ECO:0000269PubMed:7836450}.

Subcellular Localization

Secreted. Lysosome. Note=A small proportion is lysosomal.

Disease Associations

Tissue Specificity

Detected in spleen. Secreted by cultured macrophages. {ECO:0000269PubMed:7836450}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004568	chitinase activity
GO:0008061	chitin binding
GO:0008843	endochitinase activity

Biological Process

GO:0000272	polysaccharide catabolic process
GO:0005975	carbohydrate metabolic process
GO:0006032	chitin catabolic process
GO:0006955	immune response
GO:0009617	response to bacterium

Cellular Component

GO:0005615	extracellular space
GO:0005764	lysosome

Protein Structure and Domains

PDB ID

InterPro

IPR001223 Glycoside hydrolase, family 18, catalytic domain
IPR011583 Chitinase II
IPR017853 Glycoside hydrolase, superfamily
IPR029070 Chitinase insertion domain

PFAM

PF00704

PRINTS

PIRSF

SMART

SM00636

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13231