InnateDB Protein
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IDBP-48598.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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KRTAP1-3
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Protein Name
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keratin associated protein 1-3
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000344420
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InnateDB Gene
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IDBG-281648 (KRTAP1-3)
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Protein Structure
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Function |
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone. {ECO:0000269PubMed:11279113}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0030280
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structural constituent of epidermis
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002494
Keratin-associated protein
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PFAM |
PF01500
PF13885
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8IUG1
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
81850
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UniGene |
Hs.534495
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RefSeq |
NP_112228
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HUGO |
HGNC:16771
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OMIM |
608820
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CCDS |
CCDS42323
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HPRD |
12305
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IMGT |
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EMBL |
AB081338
AB081339
AJ406927
BC069161
BC101150
BC101151
BC101152
BC101153
X63338
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GenPept |
AAH69161
AAI01151
AAI01152
AAI01153
AAI01154
BAC15619
BAC15620
CAA44938
CAC27566
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