InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD47

Summary

InnateDB Protein

IDBP-48746.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD47

Protein Name

CD47 molecule

Synonyms

IAP; MER6; OA3;

Species

Homo sapiens

Ensembl Protein

ENSP00000347512

InnateDB Gene

IDBG-48744 (CD47)

Protein Structure

UniProt Annotation

Function

Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection. {ECO:0000250, ECO:0000269PubMed:11509594, ECO:0000269PubMed:15383453, ECO:0000269PubMed:7691831}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:7691831}; Multi-pass membrane protein {ECO:0000269PubMed:7691831}.

Disease Associations

Tissue Specificity

Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0070053	thrombospondin receptor activity

Biological Process

GO:0007155	cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0022409	positive regulation of cell-cell adhesion
GO:0030198	extracellular matrix organization
GO:0050870	positive regulation of T cell activation
GO:0050900	leukocyte migration