InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MS4A2

Summary

InnateDB Protein

IDBP-48888.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MS4A2

Protein Name

membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)

Synonyms

APY; ATOPY; FCER1B; FCERI; IGEL; IGER; IGHER; MS4A1;

Species

Homo sapiens

Ensembl Protein

ENSP00000278888

InnateDB Gene

IDBG-48886 (MS4A2)

Protein Structure

UniProt Annotation

Function

High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Found on the surface of mast cells and basophils.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	22 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0019767	IgE receptor activity
GO:0019863	IgE binding
GO:0019901	protein kinase binding
GO:0042169	SH2 domain binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0043306	positive regulation of mast cell degranulation
GO:0045087	innate immune response
GO:0050663	cytokine secretion
GO:0051279	regulation of release of sequestered calcium ion into cytosol

Cellular Component

GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0032998	Fc-epsilon receptor I complex
GO:0045121	membrane raft