Version 5.4
Homo sapiens Protein: GAS8
Summary
InnateDB Protein IDBP-48966.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GAS8
Protein Name growth arrest-specific 8
Synonyms GAS11;
Species Homo sapiens
Ensembl Protein ENSP00000268699
InnateDB Gene IDBG-48962 (GAS8)
Protein Structure
UniProt Annotation
Function Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, flagellum basal body {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Associates with microtubules. Localized to the cytoplasm of round spermatids, the tails of elongating spermatids, and mature spermatid tail bundles protruding into the lumen, and in the flagellum of epididymal spermatozoa. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in the heart, skeletal muscle, pancreas and liver. Weakly or not expressed in brain, placenta, lung and kidney. {ECO:0000269PubMed:9790751}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0017137 Rab GTPase binding
Biological Process
GO:0008285 negative regulation of cell proliferation
GO:0030317 sperm motility
GO:0034613 cellular protein localization
Cellular Component
GO:0005794 Golgi apparatus
GO:0005874 microtubule
GO:0031514 motile cilium
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95995
PhosphoSite PhosphoSite-O95995
TrEMBL H3BUA7
UniProt Splice Variant
Entrez Gene 2622
UniGene Hs.739124
RefSeq NP_001472
HUGO HGNC:4166
OMIM 605178
CCDS CCDS10992
HPRD 05533
IMGT
EMBL AC133919 AF050068 AF050069 AF050070 AF050071 AF050072 AF050073 AF050074 AF050075 AF050076 AF050077 AF050078 AF050079 AK297857 AK315261 BC104785 BC112121 CH471184
GenPept AAC69518 AAC69519 AAI04786 AAI12122 BAG37678 BAH12677 EAW66659 EAW66661

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca