InnateDB Protein
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IDBP-4920.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TIMM21
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Protein Name
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chromosome 18 open reading frame 55
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000169551
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InnateDB Gene
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IDBG-4918 (TIMM21)
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Protein Structure
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Function |
Participates in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex. TIM21 probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. {ECO:0000269PubMed:23260140}.
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Subcellular Localization |
Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006626
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protein targeting to mitochondrion
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GO:0030150
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protein import into mitochondrial matrix
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GO:0032981
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mitochondrial respiratory chain complex I assembly
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GO:0033617
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mitochondrial respiratory chain complex IV assembly
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GO:0044267
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cellular protein metabolic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR013261
Mitochondrial import inner membrane translocase subunit Tim21
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PFAM |
PF08294
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BVV7
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PhosphoSite |
PhosphoSite-Q9BVV7
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TrEMBL |
A8K1K8
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UniProt Splice Variant |
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Entrez Gene |
29090
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UniGene |
Hs.601570
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RefSeq |
NP_054896
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HUGO |
HGNC:25010
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OMIM |
615180
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CCDS |
CCDS12003
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HPRD |
13706
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IMGT |
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EMBL |
AF161503
AK289923
AK313936
BC000892
CH471117
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GenPept |
AAF29118
AAH00892
BAF82612
BAG36655
EAW66541
EAW66543
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